First off, most drunk people (I'm assuming you mean a person who is wasted or trashed) have lost most of their reasoning. To save myself aggravation I would just nod and smile. This is actually a broad question, because there are plenty of scenarios where having to "handle a drunk person" would arise, e.g. A friend being too drunk at a party, being confronted by someone really drunk on the street, going to a party where everyone is really drunk, etc. Each situation all depends on what your role is: Do you have some type of responsibility? Do you want to be around this kind of person or environment? Hope this helps, if not, elaborate and I'll try to answer better.
