How Long To Cook 2 Lb. Meatloaf In 350 Oven?

Generally, it will depend on the way you are cooking the meatloaf and will be determined by factors such as whether it is covered with foil or left uncovered. It may also depend on the type of oven you have and how old it is, as some ovens become less effective the older they are. In general though, left uncovered a 2lb meatloaf in a 350 oven should cook for around 80 minutes. This time should only be considered as a guideline though as all oven appliances may vary.
If you are cooking the meatloaf with a sauce or in another way, this may also affect the length of time it takes to cook. As part of the meal, if you are making other side dishes too such as roast potatoes for example that also need to cook in the oven, this may make it longer overall for both dishes to cook.
The shelf you use in the oven may also affect the cooking time. Try not to put the dish too close to the top of the oven as this may cause the top of the meatloaf to burn while the centre remains uncooked. In the same way, try not to put it at the bottom of the oven where it might take longer for it to cook. The best option is to place it on a middle shelf at 350.

I bake a 2 lb. Meatloaf for at least 1 hour. If you want the outside to be a little crusty, (and I do), I bake it at 425 or 450 degrees.

In order to be safe, you should cook it until the internal temperature reaches 160 degrees F.  This will be about 1 - 1.5 hours at 350 degrees.

I usually cook a bread pan size meatloaf 45-60 minutes. Two pounds sounds like maybe 1/2 of a bread pan so maybe 30-40 minutes. I usually cut off an end slice to make sure the meat is cooked.